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2 edition of measurement of the radiosensitivity of murine lymphoma cells. found in the catalog.

measurement of the radiosensitivity of murine lymphoma cells.

Raymond Sydney Bush

measurement of the radiosensitivity of murine lymphoma cells.

by Raymond Sydney Bush

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  • 10 Currently reading

Published in [Toronto] .
Written in English

    Subjects:
  • Lymphoma,
  • Radiation

  • Edition Notes

    ContributionsBruce, W. Robert, Toronto, Ont. University.
    Classifications
    LC ClassificationsLE3 T525 MA 1964 B877
    The Physical Object
    Pagination54 leaves.
    Number of Pages54
    ID Numbers
    Open LibraryOL14745335M

    The radiosensitivity of a transplantable murine adenocarcinoma decreased with increasing tumor volume. In unanesthetized mice this phenomenon (based on the effect of the hypoxic cell sensitizer misonidazole), in the range of volumes studied, can largely be explained by the appearance of hypoxic cells in the tumor during growth. S Lukiewicz's 24 research works with citations and reads, including: Appearance of Iron-Nitrosyl Complexes in Murine LY Lymphoma as a Function of the Form of Growth and the Type of Host.

    Non-Hodgkin lymphoma: C3H/HeN (H-2 k) Syngeneic (ii) Immunocompetent: Myc5-M5 (m) n.d. SCID mice (H-2 d) Allogenic: Immunodeficient: Splenic Hodgkin lymphoma cells (h) Hodgkin disease: Nude mice (H-2 b) Xenogenic (iii) T-cell deficiency: Human hodgkin cell line (h) Hodgkin disease: SCID mice (H-2 d) Xenogenic (iii) Immunodeficient: Ramos (h.   Nine human tumour cell lines (four mammary, one bladder, two prostate, one cervical, and one squamous cell carcinoma) were studied as to whether cellular radiosensitivity is .

    The inherent radiosensitivity of most non‐Hodgkin lymphomas (NHL), and the availability of a good antigenic target (CD20) and corresponding monoclonal antibody provided the rationale for the development of radioimmunotherapy (RIT) for the treatment of B‐cell NHL. 4, 5 RIT, which involves the administration of radionuclides linked to highly specific antibodies, can potentially treat. which squamous cell carcinoma is common, seem to be good indications for radiotherapy. However, even among squamous cell carci-Table 1 Factors Affecting Tumor Radiosensitivity 1. Histologic type • High sensitivity: Malignant lymphoma, Seminoma, etc. • Moderate sensitivity: Epithelial tumor (Carcinoma) • Low sensitivity: Osteosarcoma.


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Measurement of the radiosensitivity of murine lymphoma cells by Raymond Sydney Bush Download PDF EPUB FB2

Radiation effects on murine peripheral blood cell counts. An overview of radiation sensitivity of murine peripheral blood cells is depicted in Table 1.

Kajioka et al. described acute effects of TBI on the immune system of mice exposed to a single dose of 3 Gy. At four days after exposure they observed the highest degree of Cited by: Radiosensitivity of L/ murine lymphoma was studied in vivo by means of Co60 pump radiations.

The dosage necessary to inactivate these cells was from 5, to 6, rads applied in an only dose. Doses under 2, to 4, rads only achieved partial inactivation, proportional to dosage applied. to rad doses did not produce adverse Cited by: 2. FISCHER1 devised a medium in which murine leukæmia cells (L Y) can be grown in free culture starting from a single cell.

These cells have retained their strain specificity and Cited by: To this end, we used two murine lymphoma cell lines, the metastatic T2 and the nonmetastatic T2 cells. Although both cell lines give rise to a thymic lymphoid tumor after intrathymic inoculation in histocompatible mice, only the T2 cells induced massive tumor growth in kidneys, spleen, and liver 6 to 8 weeks postinjection.

Cited by:   Radiosensitivity of L/ murine lymphoma was studied in vivo by means of Co60 pump radiations. The dosage necessary to inactivate these cells was from 5, to 6, rads applied in an only dose.

Doses under 2, to 4, rads only achieved partial inactivation, proportional to dosage applied. to rad doses did not produce adverse Cited by: 2.

ALEXANDER P. Mouse lymphoma cells with different radiosensitivities. Nature. Nov 11; – [Beer JZ, Budzicka E, Niepokojczycka E, Rosiek O, Szumiel I, Walicka M. Loss of tumorigenicity with simultaneous changes in radiosensitivity and photosensitivity during in vitro growth of LY murine lymphoma cells.

Radiotherapy is an effective treatment modality for B-cell malignancies and is used in single and combined modality treatments [Goel et al., b; Witzig, ] Other modalities like chemotherapy.

To compare the lymphomas with intractable CLL and responsive CLL, the radiosensitivity of murine lymphoma cells was measured by per cent effects following X-irradiation of lymphoma cells with Rad and incubation for 4 hours.

A frequency distribution of the radiosensitivity of 18 lymphomas was bimodal. REGULAR ARTICLE Accelerated, but not conventional, radiotherapy of murine B-cell lymphoma induces potent T cell–mediated remissions Suparna Dutt,1 Michelle B. Atallah, 2Yoshitaka Minamida, Alexander Filatenkov,1 Kent P.

Jensen,1 Bettina P. Iliopoulou,3 Rasa Tamosiuniene,4 Jeffrey Waters, 1Edgar G. Engleman,2 and Samuel Strober 1Division of Immunology and Rheumatology, Department. The UV nm-sensitive, tumorigenic murine lymphoma cell line LY-R undergoes spontaneous conversion into a UV nm-resistant, non-tumorigenic LY-S subline after prolonged culture in we describe that this conversion leads to distinct changes in several features of intranuclear ADP-ribose polymer metabolism, which may contribute to the altered processing of DNA damage in these cells.

Abstract. The aim of radiotherapy is to kill tumor cells in a primary tumor, in draining lymph nodes, and/or in small metastatic lesions. The response of tumor cells to radiation depends on the dose, an individual’s radiosensitivity, the duration of radiation exposure (i.e., the timing), the fraction size, and the presence of other variables (e.g., chemotherapy).

The organization, administration, and financing of extra-curricular activities in Wisconsin high schools, by W. Robert Bruce () 2 editions published in in English and held by 2 WorldCat member libraries worldwide. Telomere length in radiosensitive murine lymphoma cells LY-S has been shown to be seven-fold shorter than in radioresistant cells and a significant inverse correlation between telomere length and chromosomal radiosensitivity has previously been observed in lymphocytes from 24 breast cancer patients and 5 normal individuals (McIlrath et al.

Mariette Gerber () Radiosensitivity of Murine T-Lymphocyte ion Research: NovemberVol. No. 2, pp. Eric J. Hall, James D. Cox, in Radiation Oncology (Ninth Edition), Intrinsic Radiosensitivity. The radiosensitivity of normal tissues and tumors varies considerably among individuals; for any group of patients given the same treatment, some will experience more severe reactions than others, and a small proportion will experience unacceptable late sequelae.

The radiation response of 15 mammalian cell lines comprising 11 human tumour, two human fibroblast and two murine lymphoma cell lines, has been analysed using the linear-quadratic equation.

As well as using conventional analysis of acute dose-survival curves to derive values for alpha and beta (term. A new assay is described that measures the numbers (n) of endogenous long-term repopulating cells (eLTRC) surviving sublethal assay is based on analysis of variances of Pgk-1 a phenotypes within groups of sublethally irradiated Pgk-1 a/b mice.

When ln n is plotted as a function of dose, the radiosensitivity (D 0) is the negative reciprocal of the slope and the y-intercept is N. Telomere lengths in radiosensitive murine lymphoma cells LY-S and parental radioresistant LY cells were measured by quantitative fluorescence in situ hybridization.

Figure 1. A, clonogenic survival of DNA-PKcs −/− FSC cells, and the same cells transfected with DNA-PKcs +/+ (T53) following Cs irradiation in ence intervals are 1 SD. B, absence of human DNA-PKcs in FSC and the integration of DNA-PKcs into the genome of transfected FSC (T53) cells.

The primer sequences employed do not recognize murine DNA-PKcs of mutated FSC. Catheryn M. Yashar MD, FACR, FACRO, in Clinical Gynecologic Oncology (Ninth Edition), Radiosensitivity.

Radiosensitivity is the response of the tumor to irradiation that can be measured by the extent of regression, rapidity of response, and response durability. Radiosensitivity depends on several factors.

These factors include the ability to repair damage, hypoxia, cell cycle position. The Wingless-type protein 7a (Wnt7a) plays an antiproliferative role in non-small-cell lung cancer (NSCLC). Previous studies have indicated that Wnt7a expression was downregulated in radiation-resistant NSCLC cells.

However, little is known about its biological functions and molecular mechanisms in radiosensitivity of NSCLC. Thus, NSCLC cell proliferation and apoptosis in response to Wnt7a.Tumor radiosensitivity was significantly enhanced by inhibition of pro-survival signalling molecules ERK or Nrf-2 or thioredoxin.

baicalein induced cell death in murine T cell lymphoma via.The radiosensitivity of the RM-1 cells was determined by clonogenic assays. The apoptosis of the RM-1 cells were detected by flow cytometry assay, then quantitative polymerase chain reaction assays were performed to determine the expression level of Bcl-xl mRNA in the RM-1 cells.